Blood pressure and ageing: longitudinal cohort study.

نویسندگان

  • J M Starr
  • S Inch
  • S Cross
  • W J MacLennan
  • I J Deary
چکیده

Serious instability occurred only with ergometrine injection. This result is in line with two earlier longitudinal studies during transport to and within tropical countries, in which only ergometrine injection, methylergometrine injection, and retinol capsules showed a loss of active ingredient; 12 other essential drugs were stable. 5 As all three studies focused on essential drugs suspected of being unstable we conclude that, even under the most adverse tropical conditions, clinically relevant instability of essential drugs is rare. Poor initial quality (as with ampicillin, retinol, and ergometrine in our study) poses a much more serious problem as it could, in principle, occur with any drug. The practical implication of this conclusion is that careful selection of suppliers and quality control at the entry point of the distribution chain are essential to ensure drug quality. Even in tropical climates subsequent quality checks at the district level are not necessary.

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عنوان ژورنال:
  • BMJ

دوره 317 7157  شماره 

صفحات  -

تاریخ انتشار 1998